Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and necrosis of androgen-dependent LNCaP a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gafar, Ahmed A., Draz, Hossam M., Goldberg, Alexander A., Bashandy, Mohamed A., Bakry, Sayed, Khalifa, Mahmoud A., AbuShair, Walid, Titorenko, Vladimir I., Sanderson, J. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119235/
https://www.ncbi.nlm.nih.gov/pubmed/27896021
http://dx.doi.org/10.7717/peerj.2445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119235/
https://www.ncbi.nlm.nih.gov/pubmed/27896021
http://dx.doi.org/10.7717/peerj.2445

Ejemplares similares