Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells

OBJECTIVE: The objective of this study was to investigate the mechanism of sensitivity to methotrexate (MTX) in human choriocarcinoma cells regarding DNA damage response. METHODS: Two choriocarcinoma cancer cell lines, JAR and JEG-3, were utilized in this study. An MTX-sensitive osteosarcoma cell li...

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Detalles Bibliográficos
Autores principales: Xie, Lisha, Zhao, Tiancen, Cai, Jing, Su, You, Wang, Zehua, Dong, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119623/
https://www.ncbi.nlm.nih.gov/pubmed/27895503
http://dx.doi.org/10.2147/OTT.S116387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119623/
https://www.ncbi.nlm.nih.gov/pubmed/27895503
http://dx.doi.org/10.2147/OTT.S116387

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