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Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells

OBJECTIVE: The objective of this study was to investigate the mechanism of sensitivity to methotrexate (MTX) in human choriocarcinoma cells regarding DNA damage response. METHODS: Two choriocarcinoma cancer cell lines, JAR and JEG-3, were utilized in this study. An MTX-sensitive osteosarcoma cell li...

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Detalles Bibliográficos
Autores principales:	Xie, Lisha, Zhao, Tiancen, Cai, Jing, Su, You, Wang, Zehua, Dong, Weihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119623/ https://www.ncbi.nlm.nih.gov/pubmed/27895503 http://dx.doi.org/10.2147/OTT.S116387

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