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Small Molecule Control of Protein Function through Staudinger Reduction
Using small molecules to control the function of proteins in live cells with complete specificity is highly desirable, but challenging. Here we report a small molecule switch that can be used to control protein activity. The approach uses a phosphine-mediated Staudinger reduction to activate protein...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119652/ https://www.ncbi.nlm.nih.gov/pubmed/27768095 http://dx.doi.org/10.1038/nchem.2573 |