Palmitoylated APP Forms Dimers, Cleaved by BACE1

A major rate-limiting step for Aβ generation and deposition in Alzheimer’s disease brains is BACE1-mediated cleavage (β-cleavage) of the amyloid precursor protein (APP). We previously reported that APP undergoes palmitoylation at two cysteine residues (Cys(186) and Cys(187)) in the E1-ectodomain. 8–...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Raja, Fenn, Rebecca H., Barren, Cory, Tanzi, Rudolph E., Kovacs, Dora M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119739/
https://www.ncbi.nlm.nih.gov/pubmed/27875558
http://dx.doi.org/10.1371/journal.pone.0166400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119739/
https://www.ncbi.nlm.nih.gov/pubmed/27875558
http://dx.doi.org/10.1371/journal.pone.0166400

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