AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

Loss of epithelial polarity impacts organ development and function; it is also oncogenic. AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protects the epithelial barrier against stress and suppresses tumorigenesis....

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Detalles Bibliográficos
Autores principales: Aznar, Nicolas, Patel, Arjun, Rohena, Cristina C, Dunkel, Ying, Joosen, Linda P, Taupin, Vanessa, Kufareva, Irina, Farquhar, Marilyn G, Ghosh, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119889/
https://www.ncbi.nlm.nih.gov/pubmed/27813479
http://dx.doi.org/10.7554/eLife.20795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119889/
https://www.ncbi.nlm.nih.gov/pubmed/27813479
http://dx.doi.org/10.7554/eLife.20795

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