Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

Janus kinases (JAKs) are a family of cytoplasmatic tyrosine kinases that are attractive targets for the development of anti-inflammatory drugs given their roles in cytokine signaling. One question regarding JAKs and their inhibitors that remains under intensive debate is whether JAK inhibitors shoul...

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Detalles Bibliográficos
Autores principales: Forster, Michael, Chaikuad, Apirat, Bauer, Silke M., Holstein, Julia, Robers, Matthew B., Corona, Cesear R., Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119931/
https://www.ncbi.nlm.nih.gov/pubmed/27840070
http://dx.doi.org/10.1016/j.chembiol.2016.10.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119931/
https://www.ncbi.nlm.nih.gov/pubmed/27840070
http://dx.doi.org/10.1016/j.chembiol.2016.10.008

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