Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility

Release of cytokines, growth factors and other life-essential molecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated with high substrate-specificity. We hypothesized that this is achieved by cleavage-regulatory intracellular-domain (ICD)-modifications of the precursors....

Descripción completa

Detalles Bibliográficos
Autores principales: Parra, Liseth M., Hartmann, Monika, Schubach, Salome, Ma, Junzhi, Herrlich, Peter, Herrlich, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120278/
https://www.ncbi.nlm.nih.gov/pubmed/27876763
http://dx.doi.org/10.1038/srep37464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120278/
https://www.ncbi.nlm.nih.gov/pubmed/27876763
http://dx.doi.org/10.1038/srep37464

Ejemplares similares