In Silico Exploration for Novel Type-I Inhibitors of Tie-2/TEK: The Performance of Different Selection Strategy in Selecting Virtual Screening Candidates

The receptor tyrosine kinase Tie-2 is involved in vessel remodeling and maturation, and has been regarded as a potential target for the treatment of various solid tumors. The absence of novel, potent and selective inhibitors severely hampers the understanding of the therapeutic potential of Tie-2. I...

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Detalles Bibliográficos
Autores principales: Pan, Peichen, Sun, Huiyong, Liu, Hui, Li, Dan, Zhou, Wenfang, Kong, Xiaotian, Li, Youyong, Yu, Huidong, Hou, Tingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120310/
https://www.ncbi.nlm.nih.gov/pubmed/27876862
http://dx.doi.org/10.1038/srep37628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120310/
https://www.ncbi.nlm.nih.gov/pubmed/27876862
http://dx.doi.org/10.1038/srep37628

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