Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

Protein misfolding is common across many neurodegenerative diseases, with misfolded proteins acting as seeds for "prion-like" conversion of normally folded protein to abnormal conformations. A central hypothesis is that misfolded protein accumulation, spread, and distribution are restricte...

Descripción completa

Detalles Bibliográficos
Autores principales: Alibhai, James, Blanco, Richard A., Barria, Marcelo A., Piccardo, Pedro, Caughey, Byron, Perry, V. Hugh, Freeman, Tom C., Manson, Jean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120774/
https://www.ncbi.nlm.nih.gov/pubmed/27880767
http://dx.doi.org/10.1371/journal.pbio.1002579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120774/
https://www.ncbi.nlm.nih.gov/pubmed/27880767
http://dx.doi.org/10.1371/journal.pbio.1002579

Ejemplares similares