Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition

Cardiac dysfunction caused by the impairment of myocardial contractility has been recognized as an important factor contributing to the high mortality in sepsis. Calpain activation in the heart takes place in response to increased intracellular calcium influx resulting in proteolysis of structural a...

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Detalles Bibliográficos
Autores principales: Freitas, Ana Caroline Silva, Figueiredo, Maria Jose, Campos, Erica Carolina, Soave, Danilo Figueiredo, Ramos, Simone Gusmao, Tanowitz, Herbert B., Celes, Mara Rúbia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120800/
https://www.ncbi.nlm.nih.gov/pubmed/27880847
http://dx.doi.org/10.1371/journal.pone.0166839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120800/
https://www.ncbi.nlm.nih.gov/pubmed/27880847
http://dx.doi.org/10.1371/journal.pone.0166839

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