T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

Knowledge of the processes that underlie IgG subclass switching could inform strategies designed to counteract infections and autoimmunity. Here we show that TLR7 ligands induce subsets of memory CD4 and CD8 T cells to secrete interferon γ (IFNγ) in the absence of antigen receptor stimulation. In tu...

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Detalles Bibliográficos
Autores principales: Rubtsova, Kira, Rubtsov, Anatoly V., Halemano, Kalani, Li, Sam X., Kappler, John W., Santiago, Mario L., Marrack, Philippa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120817/
https://www.ncbi.nlm.nih.gov/pubmed/27880772
http://dx.doi.org/10.1371/journal.pone.0166322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120817/
https://www.ncbi.nlm.nih.gov/pubmed/27880772
http://dx.doi.org/10.1371/journal.pone.0166322

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