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Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals

The increased paternal age at conception (PAC) has been associated with autism spectrum disorder (ASD), schizophrenia and other neurodevelopmental disorders, thus raising questions that imply, potential health concerns in the offspring. As opposed to female oogonia, the male germ cells undergo hundr...

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Detalles Bibliográficos
Autores principales: Nevalainen, Tapio, Kananen, Laura, Marttila, Saara, Jylhävä, Juulia, Jylhä, Marja, Hervonen, Antti, Hurme, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120832/
https://www.ncbi.nlm.nih.gov/pubmed/27880854
http://dx.doi.org/10.1371/journal.pone.0167028