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Isolation of a Defective Prion Mutant from Natural Scrapie

It is widely known that prion strains can mutate in response to modification of the replication environment and we have recently reported that prion mutations can occur in vitro during amplification of vole-adapted prions by Protein Misfolding Cyclic Amplification on bank vole substrate (bvPMCA). He...

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Detalles Bibliográficos
Autores principales: Vanni, Ilaria, Migliore, Sergio, Cosseddu, Gian Mario, Di Bari, Michele Angelo, Pirisinu, Laura, D’Agostino, Claudia, Riccardi, Geraldina, Agrimi, Umberto, Nonno, Romolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120856/
https://www.ncbi.nlm.nih.gov/pubmed/27880822
http://dx.doi.org/10.1371/journal.ppat.1006016