Studies of the autoinhibitory segment comprising residues 31–60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) at the cell surface and is internalized as a complex with the LDLR. In the acidic milieu of the sorting endosome, PCSK9 remains bound to the LDLR and prevents the LDLR from folding over itself...

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Detalles Bibliográficos
Autores principales: Wierød, Lene, Cameron, Jamie, Strøm, Thea Bismo, Leren, Trond P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121147/
https://www.ncbi.nlm.nih.gov/pubmed/27896130
http://dx.doi.org/10.1016/j.ymgmr.2016.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121147/
https://www.ncbi.nlm.nih.gov/pubmed/27896130
http://dx.doi.org/10.1016/j.ymgmr.2016.11.003

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