The genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discovery

BACKGROUND: Colorectal cancer (CRC) is a cumulative term applied to a clinically and genetically heterogeneous group of neoplasms that occur in the bowel. Based on twin studies, up to 45 % of the CRC cases may involve a heritable component. Yet, only in 5–10 % of these cases high-penetrant germline...

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Detalles Bibliográficos
Autores principales: Hahn, M. M., de Voer, R. M., Hoogerbrugge, N., Ligtenberg, M. J. L., Kuiper, R. P., van Kessel, A. Geurts
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121185/
https://www.ncbi.nlm.nih.gov/pubmed/27279102
http://dx.doi.org/10.1007/s13402-016-0284-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121185/
https://www.ncbi.nlm.nih.gov/pubmed/27279102
http://dx.doi.org/10.1007/s13402-016-0284-6

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