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High Pressure-Induced mtDNA Alterations in Retinal Ganglion Cells and Subsequent Apoptosis
Purpose: Our previous study indicated that mitochondrial DNA (mtDNA) damage and mutations are crucial to the progressive loss of retinal ganglion cells (RGCs) in a glaucomatous rat model. In this study, we examined whether high pressure could directly cause mtDNA alterations and whether the latter c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121242/ https://www.ncbi.nlm.nih.gov/pubmed/27932951 http://dx.doi.org/10.3389/fncel.2016.00254 |