Cargando…

Screening of mutations affecting protein stability and dynamics of FGFR1—A simulation analysis

Single amino acid substitutions in Fibroblast Growth Factor Receptor 1 (FGFR1) destabilize protein and have been implicated in several genetic disorders like various forms of cancer, Kallamann syndrome, Pfeiffer syndrome, Jackson Weiss syndrome, etc. In order to gain functional insight into mutation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doss, C. George Priya, Rajith, B., Garwasis, Nimisha, Mathew, Pretty Raju, Raju, Anand Solomon, Apoorva, K., William, Denise, Sadhana, N.R., Himani, Tanwar, Dike, IP.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121281/ https://www.ncbi.nlm.nih.gov/pubmed/27896051 http://dx.doi.org/10.1016/j.atg.2012.06.002

Ejemplares similares

Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA
por: Tanwar, Himani, et al.
Publicado: (2019)

Path to Facilitate the Prediction of Functional Amino Acid Substitutions in Red Blood Cell Disorders – A Computational Approach
por: B, Rajith, et al.
Publicado: (2011)

Computational Refinement of Functional Single Nucleotide Polymorphisms Associated with ATM Gene
por: George Priya Doss, C., et al.
Publicado: (2012)

BSA Nanoparticle Loaded Atorvastatin Calcium - A New Facet for an Old Drug
por: S, Sripriyalakshmi., et al.
Publicado: (2014)

Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors
por: C., George Priya Doss, et al.
Publicado: (2014)

A Network Map of FGF-1/FGFR Signaling System
por: Raju, Rajesh, et al.
Publicado: (2014)

Dimensional stability of short fibre reinforced flowable dental composites
por: Raju, Raju, et al.
Publicado: (2021)

Exploration of structural stability in deleterious nsSNPs of the XPA gene: A molecular dynamics approach
por: NagaSundaram, N, et al.
Publicado: (2011)

Lack of vaccination and associated comorbidities predispose to the need for intensive care in individuals infected with the delta variant – A case cohort study from a tertiary care hospital in New Delhi, India
por: Vaishya, Raju, et al.
Publicado: (2021)

Abdominal Epilepsy: A Rare Cause of Unexplained Abdominal Pain
por: Balabhadra, Anvesh, et al.
Publicado: (2020)

Computational Simulation Studies on the Binding Selectivity of 1-(1H-Benzimidazol-5-yl)-5-aminopyrazoles in Complexes with FGFR1 and FGFR4
por: Pan, You-Lu, et al.
Publicado: (2018)

RNA chain length and stoichiometry govern surface tension and stability of protein-RNA condensates
por: Laghmach, Rabia, et al.
Publicado: (2022)

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
por: Zhu, Qiong, et al.
Publicado: (2023)

Growth charts in FGFR2- and FGFR3-related faciocraniosynostoses
por: Ea, Caroline, et al.
Publicado: (2022)

Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
por: Facchinetti, Francesco, et al.
Publicado: (2023)

Evaluation on the Use of β-Lactamase and Aminoglycoside Modifying Enzyme Gene Sequences as Markers for the Early Detection of Antibiotic Resistance Profile of Pseudomonas aeruginosa
por: Doss, Victor A., et al.
Publicado: (2004)

Novel mutation detection of fibroblast growth factor receptor 1 (FGFR1) gene, FGFR2IIIa, FGFR2IIIb, FGFR2IIIc, FGFR3, FGFR4 gene for craniosynostosis: A prospective study in Asian Indian patient
por: Barik, Mayadhar, et al.
Publicado: (2015)

FGFR1 inhibition in lung squamous cell carcinoma: questions and controversies
por: Weeden, CE, et al.
Publicado: (2015)

FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy
por: Quintanal-Villalonga, Álvaro, et al.
Publicado: (2020)

Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
por: Weickhardt, Andrew J., et al.
Publicado: (2022)

COVID vaccination provided protection from severe disease despite low Cycle threshold (Ct) values
por: Vaishya, Raju, et al.
Publicado: (2021)

A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19)
por: Kumari, Priya, et al.
Publicado: (2021)

Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation
por: Zhang, Mingyang, et al.
Publicado: (2023)

Unveiling the Potentiality of Shikonin Derivatives Inhibiting SARS-CoV-2 Main Protease by Molecular Dynamic Simulation Studies
por: Das, Raju, et al.
Publicado: (2023)

Intrinsic FGFR2 and Ectopic FGFR1 Signaling in the Prostate and Prostate Cancer
por: Wang, Cong, et al.
Publicado: (2019)

The Evaluation of FGFR1, FGFR2 and FOXO1 in Orofacial Cleft Tissue
por: Goida, Jana, et al.
Publicado: (2022)

FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma
por: Tao, Zhanchao, et al.
Publicado: (2022)

Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors
por: Javle, Milind, et al.
Publicado: (2023)

Burden of depression and anxiety among leprosy affected and associated factors—A cross sectional study from India
por: Govindasamy, Karthikeyan, et al.
Publicado: (2021)

Characterization of antimicrobial resistance markers & their stability in Salmonella enterica serovar Typhi
por: Kumar, Yashwant, et al.
Publicado: (2017)

Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas
por: Granberg, Kirsi J, et al.
Publicado: (2017)

Expression and clinical significance of FGFR1 and FGFR2 in laryngeal squamous cell carcinoma
por: Hu, Mengdie, et al.
Publicado: (2022)

Integrating In Silico Prediction Methods, Molecular Docking, and Molecular Dynamics Simulation to Predict the Impact of ALK Missense Mutations in Structural Perspective
por: Priya Doss, C. George, et al.
Publicado: (2014)

Recovery, reusability and stability studies of beta cyclodextrin used for cholesterol removal from shrimp lipid
por: Raju, Navaneethan, et al.
Publicado: (2021)

FGFR2 genetic variants in women with breast cancer
por: Dix-Peek, Thérèse, et al.
Publicado: (2023)

Development and Validation of a Stability-Indicating RP-UPLC Method for the Estimation of Impurities in Cinacalcet Hydrochloride API and its Formulation
por: Sunil Reddy, Pingili, et al.
Publicado: (2015)

FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro
por: Künstlinger, Helen, et al.
Publicado: (2015)

Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells
por: Takehara, Toshiyuki, et al.
Publicado: (2015)

Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
por: Muthu, Muthumani, et al.
Publicado: (2018)

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
por: Yang, Chaofeng, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n3a854proih5kuo8lg4sv9ng6f