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De-novo protein function prediction using DNA binding and RNA binding proteins as a test case

Of the currently identified protein sequences, 99.6% have never been observed in the laboratory as proteins and their molecular function has not been established experimentally. Predicting the function of such proteins relies mostly on annotated homologs. However, this has resulted in some erroneous...

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Detalles Bibliográficos
Autores principales: Peled, Sapir, Leiderman, Olga, Charar, Rotem, Efroni, Gilat, Shav-Tal, Yaron, Ofran, Yanay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121330/
https://www.ncbi.nlm.nih.gov/pubmed/27869118
http://dx.doi.org/10.1038/ncomms13424