Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression

Heterozygous mutations in the UBIAD1 gene cause Schnyder corneal dystrophy characterized by abnormal cholesterol and phospholipid deposits in the cornea. Ubiad1 protein was recently identified as Golgi prenyltransferase responsible for biosynthesis of vitamin K2 and CoQ10, a key protein in the mitoc...

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Detalles Bibliográficos
Autores principales: Morales, Carlos R., Grigoryeva, Lubov S., Pan, Xuefang, Bruno, Luigi, Hickson, Gilles, Ngo, Michael H., McMaster, Christopher R., Samuels, Mark E., Pshezhetsky, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121353/
https://www.ncbi.nlm.nih.gov/pubmed/27896114
http://dx.doi.org/10.1016/j.ymgmr.2014.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121353/
https://www.ncbi.nlm.nih.gov/pubmed/27896114
http://dx.doi.org/10.1016/j.ymgmr.2014.09.001

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