Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Impaired glucose homeostasis and energy balance are integral to the pathophysiology of diabetes and obesity. Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular GlyT1 knockdown, in the dorsal vagal complex (DVC) suppresses glucose production, increases glucose...

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Detalles Bibliográficos
Autores principales: Yue, Jessica T. Y., Abraham, Mona A., Bauer, Paige V., LaPierre, Mary P., Wang, Peili, Duca, Frank A., Filippi, Beatrice M., Chan, Owen, Lam, Tony K. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121412/
https://www.ncbi.nlm.nih.gov/pubmed/27874011
http://dx.doi.org/10.1038/ncomms13501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121412/
https://www.ncbi.nlm.nih.gov/pubmed/27874011
http://dx.doi.org/10.1038/ncomms13501

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