CHFR negatively regulates SIRT1 activity upon oxidative stress

SIRT1, the NAD(+)-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity a...

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Detalles Bibliográficos
Autores principales: Kim, Myungjin, Kwon, Young Eun, Song, Jae Oh, Bae, Sung Jun, Seol, Jae Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121620/
https://www.ncbi.nlm.nih.gov/pubmed/27883020
http://dx.doi.org/10.1038/srep37578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121620/
https://www.ncbi.nlm.nih.gov/pubmed/27883020
http://dx.doi.org/10.1038/srep37578

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