The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells

Epacadostat is a novel inhibitor of indoleamine-2,3-dioxygenase-1 (IDO1) that suppresses systemic tryptophan catabolism and is currently being evaluated in ongoing clinical trials. We investigated the effects of epacadostat on (a) human dendritic cells (DCs) with respect to maturation and ability to...

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Detalles Bibliográficos
Autores principales: Jochems, Caroline, Fantini, Massimo, Fernando, Romaine I., Kwilas, Anna R., Donahue, Renee N., Lepone, Lauren M., Grenga, Italia, Kim, Young-Seung, Brechbiel, Martin W., Gulley, James L., Madan, Ravi A., Heery, Christopher R., Hodge, James W., Newton, Robert, Schlom, Jeffrey, Tsang, Kwong Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122347/
https://www.ncbi.nlm.nih.gov/pubmed/27192116
http://dx.doi.org/10.18632/oncotarget.9326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122347/
https://www.ncbi.nlm.nih.gov/pubmed/27192116
http://dx.doi.org/10.18632/oncotarget.9326

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