Cargando…

DNA demethylating agent decitabine broadens the peripheral T cell receptor repertoire

PURPOSE: Decitabine, a promising epi-immunotherapeutic agent has shown clinical responses in solid tumor patients, while the anti-tumor mechanisms were unclear. We aimed to investigate the immunomodulatory effect of decitabine in peripheral T cells. EXPERIMENTAL DESIGN: We applied next-generation se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nie, Jing, Zhang, Yan, Li, Xiang, Chen, Meixia, Liu, Chuanjie, Han, Weidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122357/ https://www.ncbi.nlm.nih.gov/pubmed/27191266 http://dx.doi.org/10.18632/oncotarget.9352

Ejemplares similares

Broadening the repertoire of melanoma-associated T-cell epitopes
por: Frøsig, Thomas Mørch, et al.
Publicado: (2015)

Azacytidine and Decitabine Induce Gene-Specific and Non-Random DNA Demethylation in Human Cancer Cell Lines
por: Hagemann, Sabine, et al.
Publicado: (2011)

Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature
por: Serravalle, Salvatore, et al.
Publicado: (2016)

An open-label, single-arm, phase I/II study of lower-dose decitabine based therapy in patients with advanced hepatocellular carcinoma
por: Mei, Qian, et al.
Publicado: (2015)

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer
por: Ramakrishnan, Swathi, et al.
Publicado: (2017)

Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8(+) progenitor exhausted T cell expansion in tumor models
por: Li, Xiang, et al.
Publicado: (2023)

Decitabine and Cisplatin are Synergistic to Exert Anti-Tumor Effect on Gastric Cancer via Inducing Sox2 DNA Demethylation
por: Zhu, Zhipeng, et al.
Publicado: (2021)

Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway
por: Jin, Yulong, et al.
Publicado: (2019)

Efficacy of decitabine-loaded gelatinases-stimuli nanoparticles in overcoming cancer drug resistance is mediated via its enhanced demethylating activity to transcription factor AP-2 epsilon
por: Hong, Yi-Dong, et al.
Publicado: (2017)

Spotlight on decitabine for myelodysplastic syndromes in Chinese patients
por: Jing, Yu, et al.
Publicado: (2015)

Improved clinical outcome in a randomized phase II study of anti-PD-1 camrelizumab plus decitabine in relapsed/refractory Hodgkin lymphoma
por: Liu, Yang, et al.
Publicado: (2021)

Phase Ib/II study of safety and efficacy of low‐dose decitabine‐primed chemoimmunotherapy in patients with drug‐resistant relapsed/refractory alimentary tract cancer
por: Chen, Meixia, et al.
Publicado: (2018)

Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents
por: Gallimore, Fallon, et al.
Publicado: (2023)

Low Arousing Positive Affect Broadens Visual Attention and Alters the Thought-Action Repertoire While Broadened Visual Attention Does Not
por: Jäger, Daniel T., et al.
Publicado: (2016)

Higher‐order interactions of Bcr‐Abl can broaden chronic myeloid leukemia (CML) drug repertoire
por: Liu, Yonglan, et al.
Publicado: (2023)

Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways
por: Tomar, Tushar, et al.
Publicado: (2016)

Low-Dose Decitabine-Based Chemoimmunotherapy for Patients with Refractory Advanced Solid Tumors: A Phase I/II Report
por: Fan, Hui, et al.
Publicado: (2014)

Long‐term complete remission and peripheral biomarkers in Hodgkin lymphoma patients after decitabine‐plus‐camrelizumab epi‐immunotherapy and treatment cessation
por: Wang, Chunmeng, et al.
Publicado: (2023)

The potential influence of breast cancer estrogen receptors’ distribution on active DNA demethylation
por: Linowiecka, Kinga, et al.
Publicado: (2019)

Demethylating Agents in the Treatment of Cancer
por: Howell, Paul M., et al.
Publicado: (2010)

The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma
por: Maes, Ken, et al.
Publicado: (2014)

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation
por: Dong, Cheng, et al.
Publicado: (2014)

IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia
por: Huuhtanen, Jani, et al.
Publicado: (2022)

DNA demethylation is a driver for chick retina regeneration
por: Luz-Madrigal, Agustín, et al.
Publicado: (2020)

Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation
por: Al-Romaih, Khaldoun, et al.
Publicado: (2007)

Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients
por: Costa, Nuno, et al.
Publicado: (2011)

DNA Methylation and Demethylation in Mammals
por: Chen, Zhao-xia, et al.
Publicado: (2011)

DNA methylation and demethylation dynamics
por: Neri, Francesco, et al.
Publicado: (2015)

Active DNA Demethylation in Plants
por: Parrilla-Doblas, Jara Teresa, et al.
Publicado: (2019)

Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
por: Wang, Yao, et al.
Publicado: (2021)

The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients
por: Jiang, Xuejie, et al.
Publicado: (2015)

Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ(+) CD4(+) T Cells Through Enhancing IκBα Degradation and NF-κB Activation
por: Li, Xiang, et al.
Publicado: (2021)

Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents
por: Kang, Minjeong, et al.
Publicado: (2022)

Regulation of DNA demethylation by the XPC DNA repair complex in somatic and pluripotent stem cells
por: Ho, Jaclyn J., et al.
Publicado: (2017)

Early de novo DNA methylation and prolonged demethylation in the muscle lineage
por: Tsumagari, Koji, et al.
Publicado: (2013)

Impaired DNA demethylation of C/EBP sites causes premature aging
por: Schäfer, Andrea, et al.
Publicado: (2018)

Decitabine reactivated pathways in platinum resistant ovarian cancer
por: Fang, Fang, et al.
Publicado: (2014)

TRADES: Targeted RNA Demethylation by SunTag System
por: Mo, Jing, et al.
Publicado: (2020)

Genome-wide DNA demethylation in mammals
por: Sanz, Lionel A, et al.
Publicado: (2010)

DNA Demethylation Pathways: Recent Insights
por: Li, Cong-jun
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_d7nfqr6j59e3e85j3h2c9n65fs