Targeting DNA repair with aphidicolin sensitizes primary chronic lymphocytic leukemia cells to purine analogs

Purine analogs are among the most effective chemotherapeutic drugs for the treatment of chronic lymphocytic leukemia (CLL). However, chemoresistance and toxicity limit their clinical use. Here, we report that the DNA polymerase inhibitor aphidicolin, which displayed negligible cytotoxicity as a sing...

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Detalles Bibliográficos
Autores principales: Starczewska, Eliza, Beyaert, Maxime, Michaux, Lucienne, Vekemans, Marie-Christiane, Saussoy, Pascale, Bol, Vanesa, Echarri, Ainhoa Arana, Smal, Caroline, Van Den Neste, Eric, Bontemps, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122396/
https://www.ncbi.nlm.nih.gov/pubmed/27223263
http://dx.doi.org/10.18632/oncotarget.9525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122396/
https://www.ncbi.nlm.nih.gov/pubmed/27223263
http://dx.doi.org/10.18632/oncotarget.9525

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