High throughput chemical library screening identifies a novel p110-δ inhibitor that potentiates the anti-myeloma effect of bortezomib

Multiple myeloma (MM) remains an incurable plasma cell malignancy and drug resistance persists as the major cause of treatment failure leading to fatal outcomes. The phosphatidyl-inositol-3-kinase (PI3K) pathway is constitutively hyperactivated in MM to promote disease progression and drug resistanc...

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Detalles Bibliográficos
Autores principales: Malek, Ehsan, Driscoll, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122408/
https://www.ncbi.nlm.nih.gov/pubmed/27229530
http://dx.doi.org/10.18632/oncotarget.9568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122408/
https://www.ncbi.nlm.nih.gov/pubmed/27229530
http://dx.doi.org/10.18632/oncotarget.9568

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