Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding in the flanking introns allowed no...

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Detalles Bibliográficos
Autores principales: Wongpalee, Somsakul Pop, Vashisht, Ajay, Sharma, Shalini, Chui, Darryl, Wohlschlegel, James A, Black, Douglas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122456/
https://www.ncbi.nlm.nih.gov/pubmed/27882870
http://dx.doi.org/10.7554/eLife.19743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122456/
https://www.ncbi.nlm.nih.gov/pubmed/27882870
http://dx.doi.org/10.7554/eLife.19743

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