An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy

Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a c...

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Detalles Bibliográficos
Autores principales: Golovliov, Igor, Lindgren, Helena, Eneslätt, Kjell, Conlan, Wayne, Mosnier, Amandine, Henry, Thomas, Sjöstedt, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122580/
https://www.ncbi.nlm.nih.gov/pubmed/27933275
http://dx.doi.org/10.3389/fcimb.2016.00152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122580/
https://www.ncbi.nlm.nih.gov/pubmed/27933275
http://dx.doi.org/10.3389/fcimb.2016.00152

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