Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

Growing evidence suggests persistent mitochondrial permeability transition pore (mPTP) opening is a key pathophysiological event in cell death underlying a variety of diseases. While it has long been clear the mPTP is a druggable target, current agents are limited by off-target effects and low thera...

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Detalles Bibliográficos
Autores principales: Briston, Thomas, Lewis, Sian, Koglin, Mumta, Mistry, Kavita, Shen, Yongchun, Hartopp, Naomi, Katsumata, Ryosuke, Fukumoto, Hironori, Duchen, Michael R., Szabadkai, Gyorgy, Staddon, James M., Roberts, Malcolm, Powney, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122887/
https://www.ncbi.nlm.nih.gov/pubmed/27886240
http://dx.doi.org/10.1038/srep37798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122887/
https://www.ncbi.nlm.nih.gov/pubmed/27886240
http://dx.doi.org/10.1038/srep37798

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