Impairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activation

Parkinson’s disease (PD) is characterized by α-synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies. Although it is known that extracellular α-Syn is detected in the plasma and cerebrospinal fluid, its physiological significance remains unclear. Here, we show that extracellul...

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Detalles Bibliográficos
Autores principales: Okada, Taro, Hirai, Chihoko, Badawy, Shaymaa Mohamed Mohamed, Zhang, Lifang, Kajimoto, Taketoshi, Nakamura, Shun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122898/
https://www.ncbi.nlm.nih.gov/pubmed/27886249
http://dx.doi.org/10.1038/srep37810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122898/
https://www.ncbi.nlm.nih.gov/pubmed/27886249
http://dx.doi.org/10.1038/srep37810

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