The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

BACKGROUND: The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of RUNX1-CBFA2T1 in leukaemic cell proliferation is less clear. We examined the consequences of siRNA-mediated RUNX1-CBFA2T1 depletio...

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Detalles Bibliográficos
Autores principales: Martinez, Natalia, Drescher, Bettina, Riehle, Heidemarie, Cullmann, Claire, Vornlocher, Hans-Peter, Ganser, Arnold, Heil, Gerhard, Nordheim, Alfred, Krauter, Jürgen, Heidenreich, Olaf
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC512292/
https://www.ncbi.nlm.nih.gov/pubmed/15298716
http://dx.doi.org/10.1186/1471-2407-4-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC512292/
https://www.ncbi.nlm.nih.gov/pubmed/15298716
http://dx.doi.org/10.1186/1471-2407-4-44

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