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PEP-19 modulates calcium binding to calmodulin by electrostatic steering
PEP-19 is a small protein that increases the rates of Ca(2+) binding to the C-domain of calmodulin (CaM) by an unknown mechanism. Although an IQ motif promotes binding to CaM, an acidic sequence in PEP-19 is required to modulate Ca(2+) binding and to sensitize HeLa cells to ATP-induced Ca(2+) releas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122967/ https://www.ncbi.nlm.nih.gov/pubmed/27876793 http://dx.doi.org/10.1038/ncomms13583 |