Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression

Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown. Here by using genetic association data and functional characterization, we demonstrate that rs4487645 G>T, the most highly associated varian...

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Detalles Bibliográficos
Autores principales: Li, Ni, Johnson, David C., Weinhold, Niels, Studd, James B., Orlando, Giulia, Mirabella, Fabio, Mitchell, Jonathan S., Meissner, Tobias, Kaiser, Martin, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J., Houlston, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123067/
https://www.ncbi.nlm.nih.gov/pubmed/27882933
http://dx.doi.org/10.1038/ncomms13656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123067/
https://www.ncbi.nlm.nih.gov/pubmed/27882933
http://dx.doi.org/10.1038/ncomms13656

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