The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities

According to dogma, initiator caspases are activated through proximity-induced homodimerization, but some studies infer that during apoptosis caspase-9 may instead form a holoenzyme with the Apaf-1 apoptosome. Using several biochemical approaches, including a novel site-specific crosslinking techniq...

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Detalles Bibliográficos
Autores principales: Wu, Chu-Chiao, Lee, Sunhee, Malladi, Srinivas, Chen, Miao-Der, Mastrandrea, Nicholas J., Zhang, Zhiwen, Bratton, Shawn B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123071/
https://www.ncbi.nlm.nih.gov/pubmed/27882936
http://dx.doi.org/10.1038/ncomms13565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123071/
https://www.ncbi.nlm.nih.gov/pubmed/27882936
http://dx.doi.org/10.1038/ncomms13565

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