Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

BACKGROUND: Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML). Bcr-Abl-T315I mutation is the predominant mechanism of the acquired resistance to IM. Therefore, it is urge...

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Detalles Bibliográficos
Autores principales: Lan, Xiaoying, Zhao, Chong, Chen, Xin, Zhang, Peiquan, Zang, Dan, Wu, Jinjie, Chen, Jinghong, Long, Huidan, Yang, Li, Huang, Hongbiao, Carter, Bing Z., Wang, Xuejun, Shi, Xianping, Liu, Jinbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123219/
https://www.ncbi.nlm.nih.gov/pubmed/27884201
http://dx.doi.org/10.1186/s13045-016-0359-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123219/
https://www.ncbi.nlm.nih.gov/pubmed/27884201
http://dx.doi.org/10.1186/s13045-016-0359-x

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