Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis

BACKGROUND: The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking mitosis progression and inducing cell death. Despite, all this study, the mechanism by which SP600125 inhibits mitosis-related effects in human cervical cells (HeLa cells) remains uncle...

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Detalles Bibliográficos
Autores principales: Mili, Donia, Abid, Kaouthar, Rjiba, Imed, Kenani, Abderraouf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123282/
https://www.ncbi.nlm.nih.gov/pubmed/27924151
http://dx.doi.org/10.1186/s13039-016-0296-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123282/
https://www.ncbi.nlm.nih.gov/pubmed/27924151
http://dx.doi.org/10.1186/s13039-016-0296-y

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