A framework: make it useful to guide and improve practice of clinical trial design in smaller populations

The increased attention to design and analysis of randomised clinical trials in small populations has triggered thinking regarding the most appropriate design methods for a particular clinical research question. Decision schemes and algorithms have been proposed, with varying starting points and foc...

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Detalles Bibliográficos
Autor principal: Roes, Kit C. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123315/
https://www.ncbi.nlm.nih.gov/pubmed/27884148
http://dx.doi.org/10.1186/s12916-016-0752-x
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author Roes, Kit C. B.
author_facet Roes, Kit C. B.
author_sort Roes, Kit C. B.
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description The increased attention to design and analysis of randomised clinical trials in small populations has triggered thinking regarding the most appropriate design methods for a particular clinical research question. Decision schemes and algorithms have been proposed, with varying starting points and foci. Parmar et al. (BMC Medicine 14:183, 2016) proposed a framework designed to assist the clinical trial team in design choices during protocol preparation. Herein, further stimulus is given regarding the extent to which a framework may help change practice for the better, the careful considerations for changing the usual error levels applied and the room for innovation in clinical trial design. Please see related article: http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0722-3.
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spelling pubmed-51233152016-12-06 A framework: make it useful to guide and improve practice of clinical trial design in smaller populations Roes, Kit C. B. BMC Med Commentary The increased attention to design and analysis of randomised clinical trials in small populations has triggered thinking regarding the most appropriate design methods for a particular clinical research question. Decision schemes and algorithms have been proposed, with varying starting points and foci. Parmar et al. (BMC Medicine 14:183, 2016) proposed a framework designed to assist the clinical trial team in design choices during protocol preparation. Herein, further stimulus is given regarding the extent to which a framework may help change practice for the better, the careful considerations for changing the usual error levels applied and the room for innovation in clinical trial design. Please see related article: http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0722-3. BioMed Central 2016-11-25 /pmc/articles/PMC5123315/ /pubmed/27884148 http://dx.doi.org/10.1186/s12916-016-0752-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Roes, Kit C. B.
A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
title A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
title_full A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
title_fullStr A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
title_full_unstemmed A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
title_short A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
title_sort framework: make it useful to guide and improve practice of clinical trial design in smaller populations
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123315/
https://www.ncbi.nlm.nih.gov/pubmed/27884148
http://dx.doi.org/10.1186/s12916-016-0752-x
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