Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or nonspecific binding to unintended membrane protein targets; however, distinguishing the binding of drugs to membrane proteins from that of detergents, lipids and cofactors is challenging. Here we us...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehmood, Shahid, Marcoux, Julien, Gault, Joseph, Quigley, Andrew, Michaelis, Susan, Young, Stephen G., Carpenter, Elisabeth P., Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123592/
https://www.ncbi.nlm.nih.gov/pubmed/27874871
http://dx.doi.org/10.1038/nchem.2591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123592/
https://www.ncbi.nlm.nih.gov/pubmed/27874871
http://dx.doi.org/10.1038/nchem.2591

Ejemplares similares