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Increased mitochondrial superoxide in the brain, but not periphery, sensitizes mice to angiotensin II-mediated hypertension

Angiotensin II (AngII) elicits the production of superoxide (O(2)(•−)) from mitochondria in numerous cell types within peripheral organs and in the brain suggesting a role for mitochondrial-produced O(2)(•−) in the pathogenesis of hypertension. However, it remains unclear if mitochondrial O(2)(•−) i...

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Detalles Bibliográficos
Autores principales: Case, Adam J., Tian, Jun, Zimmerman, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124355/
https://www.ncbi.nlm.nih.gov/pubmed/27889641
http://dx.doi.org/10.1016/j.redox.2016.11.011