Distinct role of IL-1β in instigating disease in Sharpin(cpdm) mice

Mice deficient in SHARPIN (Sharpin(cpdm) mice), a member of linear ubiquitin chain assembly complex (LUBAC), develop severe dermatitis associated with systemic inflammation. Previous studies have demonstrated that components of the TNF-signaling pathway, NLRP3 inflammasome and IL-1R signaling are re...

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Detalles Bibliográficos
Autores principales: Gurung, Prajwal, Sharma, Bhesh Raj, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125001/
https://www.ncbi.nlm.nih.gov/pubmed/27892465
http://dx.doi.org/10.1038/srep36634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125001/
https://www.ncbi.nlm.nih.gov/pubmed/27892465
http://dx.doi.org/10.1038/srep36634

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