Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole

The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differentiated THP-1 cells. BZL induced P-gp and MRP2 protei...

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Detalles Bibliográficos
Autores principales: Perdomo, Virginia G, Rigalli, Juan P, Luquita, Marcelo G, Pellegrino, José M, Ruiz, María Laura, Catania, Viviana A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125048/
https://www.ncbi.nlm.nih.gov/pubmed/27783718
http://dx.doi.org/10.1590/0074-02760160080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125048/
https://www.ncbi.nlm.nih.gov/pubmed/27783718
http://dx.doi.org/10.1590/0074-02760160080

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