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Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole

The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differentiated THP-1 cells. BZL induced P-gp and MRP2 protei...

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Detalles Bibliográficos
Autores principales:	Perdomo, Virginia G, Rigalli, Juan P, Luquita, Marcelo G, Pellegrino, José M, Ruiz, María Laura, Catania, Viviana A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Instituto Oswaldo Cruz, Ministério da Saúde 2016
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125048/ https://www.ncbi.nlm.nih.gov/pubmed/27783718 http://dx.doi.org/10.1590/0074-02760160080

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