T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca(2+) Influx

CD4 T cells in human infants and adults differ in the initiation and strength of their responses. The molecular basis for these differences is not yet understood. To address this the principle key molecular events of TCR- and CD28-induced signaling in naive CD4 T cells, such as Ca(2+) influx, NFAT e...

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Detalles Bibliográficos
Autores principales: Schmiedeberg, Kristin, Krause, Hardy, Röhl, Friedrich-Wilhelm, Hartig, Roland, Jorch, Gerhard, Brunner-Weinzierl, Monika C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125607/
https://www.ncbi.nlm.nih.gov/pubmed/27893767
http://dx.doi.org/10.1371/journal.pone.0166633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125607/
https://www.ncbi.nlm.nih.gov/pubmed/27893767
http://dx.doi.org/10.1371/journal.pone.0166633

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