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T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca(2+) Influx
CD4 T cells in human infants and adults differ in the initiation and strength of their responses. The molecular basis for these differences is not yet understood. To address this the principle key molecular events of TCR- and CD28-induced signaling in naive CD4 T cells, such as Ca(2+) influx, NFAT e...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125607/ https://www.ncbi.nlm.nih.gov/pubmed/27893767 http://dx.doi.org/10.1371/journal.pone.0166633 |