An Accessory Protease Inhibitor to Increase the Yield and Quality of a Tumour-Targeting mAb in Nicotiana benthamiana Leaves

The overall quality of recombinant IgG antibodies in plants is dramatically compromised by host endogenous proteases. Different approaches have been developed to reduce the impact of endogenous proteolysis on IgGs, notably involving site-directed mutagenesis to eliminate protease-susceptible sites o...

Descripción completa

Detalles Bibliográficos
Autores principales: Jutras, Philippe V., Marusic, Carla, Lonoce, Chiara, Deflers, Carole, Goulet, Marie-Claire, Benvenuto, Eugenio, Michaud, Dominique, Donini, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125672/
https://www.ncbi.nlm.nih.gov/pubmed/27893815
http://dx.doi.org/10.1371/journal.pone.0167086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125672/
https://www.ncbi.nlm.nih.gov/pubmed/27893815
http://dx.doi.org/10.1371/journal.pone.0167086

Ejemplares similares