Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions

Massively parallel reporter assays (MPRA) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here, we present a combined experimental and computational approach, Sharpr-MPRA, that allows high-resolution analysis of thousa...

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Detalles Bibliográficos
Autores principales: Ernst, Jason, Melnikov, Alexandre, Zhang, Xiaolan, Wang, Li, Rogov, Peter, Mikkelsen, Tarjei S., Kellis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125825/
https://www.ncbi.nlm.nih.gov/pubmed/27701403
http://dx.doi.org/10.1038/nbt.3678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125825/
https://www.ncbi.nlm.nih.gov/pubmed/27701403
http://dx.doi.org/10.1038/nbt.3678

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