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Gene therapy based on interleukin-12 loaded chitosan nanoparticles in a mouse model of fibrosarcoma

OBJECTIVE(S): Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery...

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Detalles Bibliográficos
Autores principales: Soofiyani, Saiedeh Razi, Hallaj-Nezhadi, Somayeh, Lotfipour, Farzaneh, Hosseini, Akbar Mohammad, Baradaran, Behzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126226/
https://www.ncbi.nlm.nih.gov/pubmed/27917281