Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells

AKT is the frequently overexpressed and constitutively active kinase within NSCLC cells and recognized as a promising target for NSCLC treatment. However, AKT inhibition relieves the feedback inhibition of upstream receptor tyrosine kinases (RTKs) that may weaken the efficiency of AKT inhibitors. Pl...

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Detalles Bibliográficos
Autores principales: Li, Ting, Chen, Xin, Chen, Xiuping, Ma, Dik Lung, Leung, Chung Hang, Lu, Jin Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126555/
https://www.ncbi.nlm.nih.gov/pubmed/27897231
http://dx.doi.org/10.1038/srep37997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126555/
https://www.ncbi.nlm.nih.gov/pubmed/27897231
http://dx.doi.org/10.1038/srep37997

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