Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H(+) secretion

The cystic fibrosis (CF) airway surface liquid (ASL) provides a nutrient rich environment for bacterial growth including elevated glucose, which together with defective bacterial killing due to aberrant HCO(3)(−) transport and acidic ASL, make the CF airways susceptible to colonisation by respirator...

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Detalles Bibliográficos
Autores principales: Garnett, James Peter, Kalsi, Kameljit K., Sobotta, Mirko, Bearham, Jade, Carr, Georgina, Powell, Jason, Brodlie, Malcolm, Ward, Christopher, Tarran, Robert, Baines, Deborah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126573/
https://www.ncbi.nlm.nih.gov/pubmed/27897253
http://dx.doi.org/10.1038/srep37955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126573/
https://www.ncbi.nlm.nih.gov/pubmed/27897253
http://dx.doi.org/10.1038/srep37955

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