Beta 1-integrin ligation and TLR ligation enhance GM-CSF–induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties

Retinoic acid (RA)–producing CD103(+) mature dendritic cells (DCs) in mesenteric lymph nodes (MLNs) play crucial roles in gut immunity. GM-CSF and RA contribute to the expression of the RA-producing enzyme ALDH1A2. However, additional signals appeared to be required for inducing ALDH1A2(high) mature...

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Detalles Bibliográficos
Autores principales: Yokota-Nakatsuma, Aya, Ohoka, Yoshiharu, Takeuchi, Hajime, Song, Si-Young, Iwata, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126582/
https://www.ncbi.nlm.nih.gov/pubmed/27897208
http://dx.doi.org/10.1038/srep37914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126582/
https://www.ncbi.nlm.nih.gov/pubmed/27897208
http://dx.doi.org/10.1038/srep37914

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